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ساعت تحویل وبلاگ :        11:03


نویسنده: سعید ضیغم جهانی(سه شنبه 85/3/30 :: ساعت 11:13 صبح)
کاربرد نانو در آی سی

با توجه به رشد روزافزون نانو تکنولوژی در تمامی عرصه های علوم امروزه ساخت تراشه های هوشمند که قادر به تصمیم گیری منطقی با توجه به برنامه بارگذاری شده در حافظه میباشند.

locمخفف کلمه lab on chip به معنی ساخت آزمایشگر و تستر و به عبارتی ساخت یک روبات هوشمند در حد نانو میباشد که در زمینه های مختلف کاربرد دارد و تنها با لود برنامه داخل Romقادر به کنترل فرایندهای در حد نانو میباشیم.

از جمله کاربردهای آن ساخت سنسورهای الکترونیکی-شیمیایی است که به سه روش قادر به شناسایی ترکیبات خونی است که توضیحات بیشتر در متن زیر امده است.برای اطلاعات بیشتراینجارا کلیک کنید.

 electrochemical Sensing

Electrochemical biosensors use electrochemical methods for transduction. They can be subdivided in to three types:

  1. Potentiometric sensors that involve the measurement of potential of a cell at zero current. The potential will be proportional to the logarithm of the concentration of the substrate being measured.
  2. Amperometric sensors where an increasing (decreasing) potential is applied to the cell until oxidation (reduction) of the substance to be analyzed occurs. This results in sharp rise (decrease) in the cell current to give a peak current. The height of this peak current will be directly proportional to the concentration of the electroactive species.
  3. Conductimetric sensors use the relationship between the conductance and ionic species concentration to measure the concentration of the substrate.

Our simulations help designers optimize sensors in terms of process conditions, selection of buffer pH, membranes, and cell geometry, among others.

The sample problem shown demonstrates how CFDRC engineers can use thier expertise to optimize an oxygen biosensor that works on the amperometric method. Simulations have been performed to quantitatively estimate how the signal varies with oxygen concentration, as well as to understand the more complex phenomenon of sensitivity of the assay due to variations in the diffusivity of the oxygen caused by Joule heating.


Schematic of a Typical Oxygen Biosensor
(Courtesy: University of Cincinnati)


Predicted Peak Current As a Function of Oxygen Concentration in the Blood Sample


Influence of Joule Heating on
Induced Current Density




نویسنده: سعید ضیغم جهانی(پنج شنبه 85/3/11 :: ساعت 10:18 صبح)
کاربرد نانو در آی سی

 

آی سی تستر DNAآی سی تستر DNA

آی سی تست کننده وتشخیص نوع  DNA که عملیات تقویت و تشخیص نوع آنرا به عهده دارد

 در موارد تشخیص و بهبود بیماریهای خاص که نیاز به کار در حد نانو و میکروسکوپیک دارد بکار گرفته می شود

این تراشه ساخت شرکت MEMS است که در زمینه ساخت تراشه های در حجم بالا واندازه های بسیار کوچک فعالیت می کند. 

 

DNA ANALYSIS CHIP

What is DNA analysis chip (or Silicon Lab-on-Chip)?
Silicon Lab-on-Chip is a disposable, standalone, point-of-care, monolithic DNA analysis device developed by STMicroelectronics, which performs both DNA amplification and detection on the same chip.

What it does?
The DNA analysis device performs DNA amplification in microscopic channels buried in the silicon and then identifies DNA fragments on gold electrodes.

Who is it useful for?
The primary end use targeted by the DNA analysis chip is in medical diagnostics, to detect genetically related disease directly at the point of care without the delays of laboratory testing. It is a compact, inexpensive and rapid solution for point-of-care diagnostics

Why a compact solution?
Compared to traditional tests, the ST silicon lab-on-chip device offers a very compact solution that reduces the overall testing cost and delivers results in minutes. Using this technology, extremely small quantities of fluid can be analyzed. 

Since there is no practical way to clean the channels after use these devices are inevitably for single use only. In the conventional laboratory this method is done with bulky and costly equipment and can take several hours. 

What is the technology behind this device?
This device is based on Micro-Electro-Mechanical-System (MEMS) technology that applies silicon-chip manufacturing technologies to produce miniature devices with a combination of mechanical, electrical, fluidic and optical elements. DNA amplification is performed using the Polymerase Chain Reaction (PCR) technique.

Where else is MEMS used?
STMicroelectronics develops and manufactures silicon MEMS devices using in-house-developed technologies covering a broad range of applications. The micro-fluidic technology used in the DNA analysis device builds on the company’s long experience in the manufacture of inkjet printer chips combining electronic and fluidic elements.

STMicroelectronics is particularly strong in “system-on-chip” technology, and supplies chips to, inter alia, Alcatel, Nokia, Philips, Siemens and Sony, inkjet print-heads to HP, and automotive electronics systems to




نویسنده: سعید ضیغم جهانی(یکشنبه 85/3/7 :: ساعت 2:33 عصر)
کاربرد نانو در آی سی

for more help and assist please reffer to this website :

http://www.generallibrary.com/Electronics.html

a reference website that contains useful information in electerical and electeronics engineering database.




نویسنده: سعید ضیغم جهانی(یکشنبه 85/3/7 :: ساعت 2:14 عصر)
کاربرد نانو در آی سی

                             

**L.O.C IS THE MAJOR ON NANO TECHNOLOGY**

کاربرد نانو در ساخت آزمایشگاهی که توانایی تست و آنالیز اطلاعات

وتصمیم گیری منطقی با توجه به برنامه لود شده را دارا میباشد. 

Chemical Technology

A supplement highlighting the latest applications and technological aspects of research across the chemical sciences.



Towards programmable lab-on-a-chip devices


Chemists in the US have developed microfluidic valve structures for lab-on-a-chip devices that reduce the number of controllers required off the chip.

Richard Mathies and colleagues at the University of California, Berkeley, created microfluidic valves that can be held open for minutes by pressure pulses as short as 120 ms. These are controlled independently using an on-chip pneumatic demultiplexer, a device that can control many outputs from a small number of inputs. These structures allow many on-chip valves to be controlled independently using only a few off-chip components.

Microfluidic valve structure 

Lab-on-a-chip devices shrink entire chemical or biochemical assays down to small microfluidic chips. The goal is now to shrink the controls: the off-chip computers, valves, switches and pumps that operate the chip. By decreasing the number of these controllers Mathies hopes to reduce the size, power consumption and cost of the chips.

On-chip pneumatic valves and pumps play an important role in lab-on-a-chip devices, but each independent valve currently requires a separate off-chip controller. This can lead to problems because a single chip may have hundreds of these valves.

"The possibility of controlling a thousand independent valves with only eleven pneumatic controls is remarkable."
- Albert van den Berg, University of Twente

Albert van den Berg, head of the lab-on-a-chip group at the University of Twente, the Netherlands, said this work is a major contribution to the microfluidics field. ‘The possibility of controlling a thousand independent valves with only eleven pneumatic controls is remarkable,’ he said.

‘The future lies in programmable lab-on-a-chip devices, generic platforms that can perform thousands of different assays simply by providing different inputs and running different programs,’ said Mathies. ‘Integrating the basic logic of device operation on-chip is a crucial first step toward realising this goal of programmable lab-on-a-chip devices,’ he said. 

Sarah M Corcoran

BY :saeed zeigham jehani

References

W H Grover, R H C Ivester, E C Jensen and R A Mathies, Lab Chip, 2006, 6, 623


 




نویسنده: سعید ضیغم جهانی(دوشنبه 85/3/1 :: ساعت 1:29 عصر)
کاربرد نانو در آی سی